What Products Are Included in NHU's 77,815-Ton Synthetic Fragrance Project?

Shandong NHU Pharmaceutical Co., Ltd.'s synthetic fragrance project has made new progress. Its project with an annual output of 77,815 tons of synthetic fragrances has undergone a second round of environmental impact assessment (EIA) publicity on relevant websites.

Project Product Layout

Upon completion, the project will have the following production capacities:

• 17,000 tons/year of 2-methyl-3-butyn-2-ol (70% purity)
• 6,500 tons/year of 2-methyl-3-butyn-2-ol (99% purity)
• 19,065 tons/year of dehydrolinalool
• 22,000 tons/year of methyl heptenone
• 9,000 tons/year of linalool
• 250 tons/year of by-product composite fragrances
• 1,000 tons/year of Avobenzone
• 2,000 tons/year of α-iso-methyl ionone
• 1,000 tons/year of α-n-methyl ionone

Project Construction Plan

The project will be constructed in four phases. Phase I will expand the following:

• Synthetic fragrance production by 14,000 tons/year
• Isoprenol production by 16,000 tons/year
• Linalool production by 5,000 tons/year

The construction will utilize 28 sets of existing equipment, including gas holders, compressors, and reactors. The main raw materials are acetone and acetylene. The production process involves the alcoholysis reaction of acetylene and acetone to produce 2-methyl-3-butyn-2-ol (70%), which is then dehydrated to yield 2-methyl-3-butyn-2-ol (99%).

Product Applications

2-Methyl-3-butyn-2-ol

This is an important intermediate in organic synthesis with dual activity of alkyne and hydroxyl groups. In pharmaceuticals, it is an intermediate for the antidepressant Veranamine, and participates in Sonogashira coupling and cyclization reactions for the synthesis of intermediates for anti-atrial fibrillation or antihypertensive drugs. In pesticides and fragrances, it can be used to synthesize DV pyrethroids (a type of insecticide) and linalool (a fragrance compound). In materials industry, it serves as a polymerization inhibitor in platinum-catalyzed hydrosilylation reactions in silicone rubber production. It can also be used as an acid-etch inhibitor and viscosity stabilizer in coatings and plastics. Additionally, it acts as a stabilizer for chlorinated solvents and as a polymer monomer or heat transfer medium.

Dehydrolinalool

Used directly in the fragrance industry as a raw material for daily-use fragrances, it provides floral and green scent notes, commonly used in perfumes and detergents. It is also a precursor for linalool, one of the most widely used terpene fragrances globally. The double bond structure of dehydrolinalool makes it suitable for synthesizing intermediates of vitamins A and E. Its derivatives possess insect-repelling activity and can be used as natural pesticide synergists. Through cyclization, it can be converted into ionone compounds (such as α-iso-methyl ionone), or esterified into ester-type fragrances (such as dehydrolinalyl acetate).